Volume 14 Issue 3
Sep.  2021
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Ying Li, Wen Yang, Xi-qiang Zheng, Chi Yao, Yi Wu. 2021: Combining passive sampling with toxicity testing to evaluate potential ecotoxicological effects of pharmaceuticals in wastewater-impacted rivers. Water Science and Engineering, 14(3): 201-209. doi: 10.1016/j.wse.2021.08.009
Citation: Ying Li, Wen Yang, Xi-qiang Zheng, Chi Yao, Yi Wu. 2021: Combining passive sampling with toxicity testing to evaluate potential ecotoxicological effects of pharmaceuticals in wastewater-impacted rivers. Water Science and Engineering, 14(3): 201-209. doi: 10.1016/j.wse.2021.08.009

Combining passive sampling with toxicity testing to evaluate potential ecotoxicological effects of pharmaceuticals in wastewater-impacted rivers

doi: 10.1016/j.wse.2021.08.009
Funds:

This work was supported by the National Natural Science Foundation of China (Grant No. 51879077) and the project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

  • Received Date: 2020-12-09
  • Accepted Date: 2021-02-09
  • Available Online: 2021-10-11
  • A passive sampling method was employed for time-integrative monitoring of five pharmaceuticals and one transformation product (TP) in rivers impacted by sewage treatment plants, in parallel with traditional sampling methods. Target pharmaceuticals, other than naproxen, were detected through passive sampling, with average concentrations in the range of 0.2-5.8 ng/L, and through active sampling, with average concentrations in the range of 0.5-21.7 ng/L. Meanwhile, the ecotoxicological effects of pharmaceuticals and TPs were assessed, including the formation of zebrafish embryos and expression of target genes, upon exposure of zebrafish embryos to sulfadiazine (SDZ) and its TP sulfacetamide, as well as two artificial mixed rivers. The exposure results showed negligible impacts of environmental levels of SDZ, while mimic mixture exposure disturbed the development of embryos and led to the alteration of the socs3, TNF-α, and IL-1β genes. The findings of this study indicated that although pharmaceutical concentrations in rivers receiving treated wastewater are low, the potential ecological effects on the aquatic environment require more attentions.

     

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