The main purpose of this study was to forecast the inflow to Hongze Lake using the Xin anjiang rainfall-runoff model. The upper area of Hongze Lake in the Huaihe Basin was divided into 23 sub-basins, including the surface of Hongze Lake. The influence of reservoirs and gates on flood forecasting was considered in a practical and simple way. With a one-day time step, the linear and non-linear Muskingum method was used for channel flood routing, and the least-square regression model was used for real-time correction in flood forecasting. Representative historical data were collected for the model calibration. The hydrological model parameters for each sub-basin were calibrated individually, so the parameters of the Xin anjiang model were different for different sub-basins. This flood forecasting system was used in the real-time simulation of the large flood in 2005 and the results are satisfactory when compared with measured data from the flood.